Endocrine Abstracts

Background: NOD mice are the most frequently preferred animal models in type 1 diabetes (T1D) research. They develop spontaneous disease in 24 to 30 months. T1D can also chemically be induced in NOD mice for a faster disease progression. Two commonly used diabetes-inducing agents are Streptozotocin (STZ), which destructs pancreatic beta cells mainly through DNA fragmentation, and Cyclophosphamide (CY), which acts on suppressor T cells. TNF-Related Apoptosis-Inducing Ligand (TR...